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Share Give access Share full text access. Share full text access. Please review our Terms and Conditions of Use and check box below to share full-text version of article. Get access to the full version of this article. View access options below. Now that you know about various rodent tests for behavioral disorders and stress, let's look at some examples of how neuroscientists are currently using them in their research. As discussed before, to understand the neuroanatomical basis of behavioral disorders, scientists can damage specific brain regions in rodents, and then test them using behavioral tasks.
In this experiment, researchers damaged the prefrontal cortex in mice, and placed them into the successive alleys test. Results demonstrate that treated mice spend more time in the farthest and most anxiogenic alleys compared to control animals, indicating a role for the prefrontal cortex in anxiety-like behaviors.
Models can also provide insight into the genes involved in behavioral disorders. Here, researchers overexpressed a gene called DISC1, in certain brain regions of rodents, then treated these animals with either saline or amphetamine and introduced them into an open field. Results demonstrate that rodents with gene overexpression show pronounced effect of amphetamine treatment. Finally, researchers can use models to better characterize the underlying physiology of behavioral disorders. Here, scientists generated a rodent model of post-traumatic stress disorder and studied the resulting physiological changes.
To do this, researchers first stressed rodents by exposing them to electric shocks, and then looked for changes in levels of the main stress hormone, called cortisol. Cortisol levels were found to be markedly higher in the PTSD models than in their healthy counterparts. You've just watched JoVE's introduction to behavioral disorders and stress. This video reviewed why behavioral scientists are using rodent models in this field, and described validity criteria for these models.http://jennie.dev3.develag.com/88.php
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Then, we discussed key questions highlighting the unsolved problems of the field, followed by behavioral paradigms currently being used to answer these questions. As always, thanks for watching! A subscription to J o VE is required to view this content. You will only be able to see the first 20 seconds. To learn more about our GDPR policies click here. If you want more info regarding data storage, please contact gdpr jove. This is a sample clip. If you're new to JoVE sign up and start your free trial today to watch the full video!
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Add to Favorites Embed Share. Summary Recently, it has been discovered that behavioral conditions such as, depression, anxiety and stress-response have a neurological basis. To watch full video, login or sign up! If your institution is subscribed to the Behavioral Science. Deacon 1. Terrillion 3 , Sean C. Piantadosi 1 , Shambhu Bhat 1 , Todd D.
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Rho 1 , Susan A. Masino 2 , Richelle Mychasiuk 1. Biology II. An Introduction to the Laboratory Mouse: Mus musculus. Basic Mouse Care and Maintenance. An Introduction to Behavioral Neuroscience.
Department of Psychiatry and Behavioral Sciences
Free Preview. Buy eBook. Buy Softcover. FAQ Policy. About this Textbook This book is the product of many years' experience teaching behavioral science in a way that demonstrates its relevance to clinical medicine. Show all. Memory Pages Hine, Frederick R. Intelligence Pages Hine, Frederick R.